Effect of plant polysaccharides (<i>Poria cocos</i> and <i>Astragalus</i> polysaccharides) on immune responses and intestinal microbiota of Dabry’s sturgeons

Searching for non-toxic and harmless feed ingredients that can improve growth performance host immunity has always been the focus of attention in protected areas artificially bred Dabry’s sturgeons. The present study explored effect dietary Poria cocos Astragalus polysaccharides on antioxidant status, expression immune related genes, composition putative functions gut bacterial communities sturgeons first time. In this study, were randomly divided into 3 groups fed diets normal, P. polysaccharide–added (200 mg/kg), mg/kg) food 14 days. results indicated polysaccharide increase final body weight sturgeon. Compared with normal breeding individuals, feeding containing up-regulated activity superoxide dismutase, lysozyme, catalase, glutathione peroxidase while also decreasing levels malondialdehyde. addition, group had higher gene two inflammatory cytokines, tumor necrosis factor alpha immunoglobulin M, than control group. Analysis intestinal microbiota revealed improved richness diversity major sturgeons, structure was clearly distinguished from Our preliminarily supplementation may contribute to better growth, development, response they provide basic guidance plant additives artificial